AustralieFrV1, Main, Exploration, bibRecord, 003F24

The prognostic significance of sentinel node tumour burden in melanoma patients: An international, multicenter study of 1539 sentinel node-positive melanoma patients

Identifieur interne : 003F24 ( Main/Exploration ); précédent : 003F23; suivant : 003F25

The prognostic significance of sentinel node tumour burden in melanoma patients: An international, multicenter study of 1539 sentinel node-positive melanoma patients

Auteurs : Augustinus P. T. Van Der Ploeg [Pays-Bas] ; Alexander C. J. Van Akkooi [Pays-Bas] ; Lauren E. Haydu [Australie] ; Richard A. Scolyer [Australie] ; Rajmohan Murali [États-Unis] ; Cornelis Verhoef [Pays-Bas] ; John F. Thompson [Australie] ; Alexander M. M. Eggermont [France]

Source :

European journal of cancer : (1990) [ 0959-8049 ] ; 2014.

RBID : Pascal:14-0034927

Descripteurs français

Pascal (Inist)
- Mélanome malin, Pronostic, Homme, Biopsie, International, Etude multicentrique, Anatomopathologie, Survie, Cancérologie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Anatomic pathology, Biopsy, Cancerology, Human, International, Malignant melanoma, Multicenter study, Prognosis, Survival.

Abstract

Introduction: Sentinel node (SN) biopsy (SNB) and completion lymph node dissection (CLND) when SN-positive have become standard of care in most cancer centres for melanoma. Various SN tumour burden parameters are assessed to determine the heterogeneity of SN-positivity. The aim of the present study was to validate the prognostic significance of various SN tumour burden micromorphometric features and classification schemes in a large cohort of SN-positive melanoma patients. Methods: In 1539 SN-positive patients treated between 1993 and 2008 at 11 melanoma treatment centres in Europe and Australia, indices of SN tumour burden (intranodal location, tumour penetrative depth (TPD) and maximum size of SN tumour deposits) were evaluated. Results: Non-subcapsular location, increasing TPD and increasing maximum size were all predictive factors for non-SN (NSN) status and were independently associated with poorer melanoma-specific survival (MSS). Patients with subcapsular micrometastases <0.1 mm in maximum dimension had the lowest frequency of NSN metastasis (5.5%). Despite differences in SN biopsy protocols and clinicopathologic features of the patient cohorts (between centres), most SN parameters remained predictive in individual centre populations. Maximum SN tumour size > 1 mm was the most reliable and consistent parameter independently associated with higher non-SN-positivity, poorer disease-free survival (DFS) and poorer MSS. Conclusions: In this large retrospective, multicenter cohort study, several parameters of SN tumour burden including intranodal location, TPD and maximum size provided prognostic information, but their prognostic significance varied considerably between the different centres. This could be due to sample size limitations or to differences in SN detection, removal and examination techniques.

Affiliations:

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Le document en format XML

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<series><title level="j" type="main">European journal of cancer : (1990)</title>
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<front><div type="abstract" xml:lang="en">Introduction: Sentinel node (SN) biopsy (SNB) and completion lymph node dissection (CLND) when SN-positive have become standard of care in most cancer centres for melanoma. Various SN tumour burden parameters are assessed to determine the heterogeneity of SN-positivity. The aim of the present study was to validate the prognostic significance of various SN tumour burden micromorphometric features and classification schemes in a large cohort of SN-positive melanoma patients. Methods: In 1539 SN-positive patients treated between 1993 and 2008 at 11 melanoma treatment centres in Europe and Australia, indices of SN tumour burden (intranodal location, tumour penetrative depth (TPD) and maximum size of SN tumour deposits) were evaluated. Results: Non-subcapsular location, increasing TPD and increasing maximum size were all predictive factors for non-SN (NSN) status and were independently associated with poorer melanoma-specific survival (MSS). Patients with subcapsular micrometastases <0.1 mm in maximum dimension had the lowest frequency of NSN metastasis (5.5%). Despite differences in SN biopsy protocols and clinicopathologic features of the patient cohorts (between centres), most SN parameters remained predictive in individual centre populations. Maximum SN tumour size > 1 mm was the most reliable and consistent parameter independently associated with higher non-SN-positivity, poorer disease-free survival (DFS) and poorer MSS. Conclusions: In this large retrospective, multicenter cohort study, several parameters of SN tumour burden including intranodal location, TPD and maximum size provided prognostic information, but their prognostic significance varied considerably between the different centres. This could be due to sample size limitations or to differences in SN detection, removal and examination techniques.</div>
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<name sortKey="Scolyer, Richard A" sort="Scolyer, Richard A" uniqKey="Scolyer R" first="Richard A." last="Scolyer">Richard A. Scolyer</name>
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<country name="États-Unis"><noRegion><name sortKey="Murali, Rajmohan" sort="Murali, Rajmohan" uniqKey="Murali R" first="Rajmohan" last="Murali">Rajmohan Murali</name>
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<country name="France"><noRegion><name sortKey="Eggermont, Alexander M M" sort="Eggermont, Alexander M M" uniqKey="Eggermont A" first="Alexander M. M." last="Eggermont">Alexander M. M. Eggermont</name>
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The prognostic significance of sentinel node tumour burden in melanoma patients: An international, multicenter study of 1539 sentinel node-positive melanoma patients

The prognostic significance of sentinel node tumour burden in melanoma patients: An international, multicenter study of 1539 sentinel node-positive melanoma patients

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri